Section: Application Domains

Pharmacometrics

Participants : Marc Lavielle, Kevin Bleakley, Célia Barthélémy.

Popix is directly implicated in the domain of pharmacology. Historically, Marc Lavielle was the driving force behind the pharmacological modeling software Monolix , now an industry standard. Lixoft, an Inria start-up, now develops and supports Monolix and the commercial side of things. Popix collaborates closely with Lixoft to transfer research results into software improvements and the development of new user tools in Monolix .

Popix is also majorly implicated in the 5-year DDMoRe (Drug and Disease Model Resources) European project financed by the IMI (Innovative Medicines Initiative), a public-private partnership. In particular, Popix has the task of developing new tools and methods for this project regrouping researchers in pharmacometrics, biostatistics and biology from both the public and private sectors. Specific tools and methods being developed by Popix include:

• a clinical trial simulator

• protocol optimization tools

• diagnostic tools

• model selection tools

• data exploration tools

• estimation techniques for complex models (eg, stochastic differential equations, partial differential equations)